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First Three-parent Baby

A baby boy is the first baby to be born using a new technique that incorporates DNA from three people.

This is the world’s first baby born with a new “3 parent” technique. The technique that allows parents with rare genetic mutations to have healthy babies.

The baby’s mother carries genes for Leigh syndrome – a disorder that affects the developing nervous system. The disease genes reside in the mitochondria, separate from the DNA of the nucleus. She had two babies before, but both died of the disease.

So, she sought help from John Zhang, a fertility doctor in New York. He used a technique called spindle nuclear transfer to create embryos with healthy mitochondria. Zhang removed the nuclear DNA from one of the mother’s eggs and inserted it into a donor egg with healthy mitochondria. The resulting egg was fertilised with the baby’s father’s sperm. They created 5 embryos, one of which was implanted into the mother. The baby is healthy. The procedure isn’t legal in the US, so it was done in Mexico.

A baby has been born to a previously infertile couple in Ukraine using a new type of “three-person IVF”. The baby girl was born on 5 January. She is the world’s second “modern three-parent baby”.

How Pronuclear Transfer Works